Computational Modeling Predicts Benefits of Proefferocytic Therapy in Human Atherosclerosis

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K. Jarr, K. Palm, G. Pasterkamp, M. Mokry, N. Leeper

Circulation, 2025

Smooth muscle cells in atherosclerosis: essential but overlooked translational perspectives

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P. Azar, K. Jarr, D. Gomez, H. Jorgensen, N. Leeper, M. Bochaton-Piallat

European Heart Journal, 2025

2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis

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K. Jarr, Y. Kojima, I. Weissman, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2022

The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis

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K. Jarr, J. Ye, Y. Kojima, Z. Ye, H. Gao, S. Schmid, L. Luo, R. Baylis, M. Lotfi, N. Lopez, A. Eberhard, B. Smith, I. Weissman, L. Maegdefessel, N. Leeper

Nature Cardiovascular Research, 2022

Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability

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P. Tsantilas, S. Lao, Z. Wu, A. Eberhard, G. Winski, M. Vaerst, V. Nanda, Y. Wang, Y. Kojima, J. Ye, A. Flores, K. Jarr, J. Pelisek, H. Eckstein, L. Matic, U. Hedin, P. Tsao, V. Paloschi, L. Maegdefessel, N. Leeper

Cardiovascular Research, 2021

Effect of CD47 Blockade on Vascular Inflammation.

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K. Jarr, R. Nakamoto, B. Doan, Y. Kojima, I. Weissman, R. Advani, A. Iagaru, N. Leeper

New England Journal of Medicine, 2021

18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease

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K. Jarr, Jianqin Ye, Y. Kojima, V. Nanda, Alyssa M. Flores, P. Tsantilas, Ying Wang, Niloufar Hosseini-Nassab, Anne V. Eberhard, Mozhgan Lotfi, Max Käller, B. Smith, L. Maegdefessel, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2020

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

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Y. Wang, V. Nanda, D. Direnzo, J. Ye, S. Xiao, Y. Kojima, K. Howe, K. Jarr, A. Flores, P. Tsantilas, N. Tsao, A. Rao, A. Newman, A. Eberhard, J. Priest, A. Ruusalepp, G. Pasterkamp, L. Maegdefessel, C. Miller, L. Lind, S. Koplev, J. Björkegren, G. Owens, E. Ingelsson, I. Weissman, N. Leeper

Proceedings of the National Academy of Sciences of the United States of America, 2020

Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis

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Y. Kojima, J. Ye, V. Nanda, Y. Wang, A. Flores, K. Jarr, P. Tsantilas, L. Guo, A. Finn, R. Virmani, N. Leeper

Circulation, 2020

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

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A. Flores, N. Hosseini-Nassab, K. Jarr, J. Ye, X. Zhu, R. Wirka, A. Koh, P. Tsantilas, Y. Wang, V. Nanda, Y. Kojima, Y. Zeng, M. Lotfi, R. Sinclair, I. Weissman, E. Ingelsson, B. Smith, N. Leeper

Nature Nanotechnology, 2020

Nanoparticle Therapy for Vascular Diseases

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A. Flores, J. Ye, K. Jarr, N. Hosseini-Nassab, B. Smith, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2019

Initial Single-Center Experience With the Fully Repositionable Transfemoral Lotus Aortic Valve System

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K. Jarr, F. Leuschner, B. Meder, H. Katus, R. Bekeredjian, E. Chorianopoulos

The Journal of Invasive Cardiology, 2016

Heat-shock-protein 90 protects from downregulation of HIF-1α in calcineurin-induced myocardial hypertrophy

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S. Eschricht, K. Jarr, C. Kuhn, Lorenz L. Lehmann, M. Kreusser, H. Katus, N. Frey, E. Chorianopoulos

Journal of Molecular and Cellular Cardiology, 2015

Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy

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K. Jarr, M. Nelles, H. Katus, E. Chorianopoulos

Mediators of Inflammation, 2014

TNF-Like Weak Inducer of Apoptosis Aggravates Left Ventricular Dysfunction after Myocardial Infarction in Mice

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K. Jarr, S. Eschricht, L. Burkly, M. Preusch, H. Katus, N. Frey, E. Chorianopoulos

Mediators of Inflammation, 2014

MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3

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D. Frank, J. Gantenberg, I. Boomgaarden, C. Kuhn, Rainer Will, K. Jarr, M. Eden, Kristina Kramer, M. Luedde, H. Mairbäurl, H. Katus, N. Frey

Journal of Molecular and Cellular Cardiology, 2012

Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome

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E. Chorianopoulos, K. Jarr, H. Steen, E. Giannitsis, N. Frey, H. Katus

Atherosclerosis, 2010